Among all clinical imaging modalities, optical imaging provides the highest resolution and contrast. A main research effort in our group is the study and development of optical imaging techniques that are useful for clinical applications, including minimally-invasive endoscopic techniques with minimal mechanical scanning, low coherence interferometric imaging, and reflectance confocal microscopy.

Spectrally encoded endoscopySpectrally encoded endoscopy
Endoscopes help medical procedures to be less invasive, thereby reducing the risk of complications as well as costs and recovery…
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Multi-channel spectrally encoded endoscopeMulti-channel spectrally encoded endoscope
In its current mode of implementation, SEE has several limiting factors which need to be addressed before its clinical promise…
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Imaging blood flowImaging blood flow
Optical microscopy of blood cells in vivo provides a unique opportunity for clinicians and researchers to visualize the morphology…
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Adjusting field of view using dispersionAdjusting field of view using dispersion
Utilizing Fourier-domain interferometry, spectrally encoded endoscopy (SEE) was shown capable of video-rate three-dimensional imaging…
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Lasers are becoming increasingly popular for numerous medical applications. The use of femtosecond laser pulses is particularly attractive for such applications thanks to the “cold” process of tissue ablation which is confined only to the focal volume of the laser beam. In our group we use femtosecond pulses of various wavelength to excite specifically targeted noble-metal nanoparticles at their plasmonic resonance. The combined effect of the short pulses and small particles allows for specific manipulations of cells and tissue with minimal toxicity and collateral damage.

Specific cell fusionSpecific cell fusion
The attachment between two different cells via a bispecific nanoparticle is illustrated in Figure 1a. Following the addition of the nanoparticles…
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Nano-manipulations of cellsNano-manipulations of cells
Specifically targeting and manipulating living cells is a key challenge in biomedicine and in cancer research in particular…
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Nanoparticle-pulse interactionNanoparticle-pulse interaction
Gold nanoparticles find a wide range of applications in optics and photonics; however, their detailed interaction with intense laser light is only partially understood…
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Nano-manipulations of macro-moleculesNano-manipulations of macro-molecules
The unique optical properties of gold nanoparticles make them attractive for a wide range of applications which require optical detection and manipulation techniques…
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